Debes de seleccionar un país
Inicio » Índice de Estudios Clínicos por Padecimiento » Diabetes Type 2

Metabolism and Nutrition


Diabetes Type 2

Diabetes Type 2 Iron Deficiency Anaemia
Reference

Mobini R, 2017 Sweden

Study Objectives

To evaluate metabolic effects of L. reuteri DSM 17938, in standard or high dose, in adults with type 2 dia betes on insulin treatment. Primary outcome was changes in glycated hemoglobin, secondary outcomes were insulin sensitivity (assessed by glucose clamp), liver fat content, body composition, body fat distribu tion, faecal microbiota composition and serum bile acids.

Study Design*

R, DB, PC 12 weeks

No. of Subjects (dose)

L. reuteri: 15 (1×108 CFU) L. reuteri: 14 (1×1010 CFU) Placebo: 15

Results

• Compared to baseline, subjects in the high dose group exhibited increases in insulin sensitivity index (ISI) and serum levels of the secondary bile acid deoxycholic acid (DCA).
• Compared to placebo there was no difference in outcomes at the end of the study period.
• Post hoc analysis showed that subjects who responded with increased ISI after ingestion of L. reuteri had higher microbial diversity at baseline, and increased serum levels of DCA after supplementation. In addition, increases in DCA levels correla ted with improved insulin sensitivity in the probiotic recipients.