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Safety


Safety During Pregnancy

Reference

Forsberg A, 2020
Sweden

Study Objectives

To investigate how maternal peripheral immunity is affected by pregnancy, and by probiotic and ω-3 fatty acid supple mentation.

Study Design*

R, DB, PC From gestational week 20 until birth

No. of Subjects (dose)

1) L. reuteri + ω-3 PUFA: 22
2) ω-3 PUFA + placebo: 21
3) placebo + ω-3 PUFA: 22
4) placebo capsules + placebo oil: 23 (L. reuteri: 1×109 CFU, 20 droplets × 2 daily; ω-3 PUFA: 3840 mg)

Results

No adverse events were reported in the women receiving L. reuteri.

Reference

Abrahamsson T, 2007
Sweden

Study Objectives

To evaluate prevention of atopic eczema in infants 0–2 years old where pregnant women ingested L. reuteri ATCC 55730 before giving birth.

Study Design*

R, DB, PC 4 weeks before delivery, follow-up after 1 month

No. of Subjects (dose)

L. reuteri: 95 (1×108 CFU) Placebo: 93

Results

Adverse events among mothers were not registered.

Reference

Schlagenhauf U, 2016
Germany

Study Objectives

Influence of L. reuteri Prodentis lozenges on plaque control and gingival inflam mation in pregnant women.

Study Design*

R, DB, PC During 3rd trimester and until the first days after delivery

No. of Subjects (dose)

L. reuteri: 24 (4×108 CFU) Placebo: 21

Results

Adverse events were not registered.