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Functional Gastrointestinal Disorders (FGIDs)


Irritable Bowel Syndrome (IBS)

Reference

Cruchet S, 2024
Chile / Mexico

Study Objectives

To evaluate efficacy and safety of L. reuteri DSM 17938 + ATCC PTA 6475 (Gastrus) on symptoms of IBS in adults.

Study Design*

R, DB, PC 14 weeks

No. of Subjects (dose)

L. reuteri: 70 (4×108 CFU) Placebo: 70

Results

L. reuteri Gastrus significantly improved overall IBS symp toms (GSRS-IBS score), individual scores (abdominal pain, pain relieved by a bowel action, bloating, passing gas, visible distension), Quality of Life and anxiety from treatment week 6 and onwards.

Reference
Study Objectives

To evaluate L. reuteri for treatment of mixed type IBS in adults.

Study Design*

R, DB, PC 6 months

No. of Subjects (dose)

L. reuteri: 27 (2×108 CFU) Placebo: 27

Results

Compared to placebo, L. reuteri showed strong tendency to effect on:
• Reduced gases
• Reduced constipation Study limitations: underpowered, due to only one study center of two started and completed the study